Progression to Cirrhosis Leads to Improvement in Atherogenic Milieu
| Autor: | Mohammad Bilal Siddiqui, Samarth Patel, Robert J. Minniti, Mohammad S. Siddiqui, Jose Hernandez Roman, Adam Sima, Sherry Boyett, Masoud Faridnia, Genta Kakiyama, Michael V. Patrone, Arun J. Sanyal, Anchalia Chandrakumaran, William M. Pandak, Viviana Rodríguez, Chandra Bhati, Emily Zhang, Caroline Walker, Jasmohan S. Bajaj |
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| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
Male Very low-density lipoprotein medicine.medical_specialty Cirrhosis Physiology medicine.medical_treatment Adipokine Liver transplantation Gastroenterology Coronary artery disease Cohort Studies Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Retrospective Studies Adiponectin business.industry Hepatology Middle Aged medicine.disease Atherosclerosis Liver Transplantation Cardiovascular Diseases Disease Progression Female Inflammation Mediators business Follow-Up Studies |
| Zdroj: | Digestive diseases and sciences. 66(1) |
| ISSN: | 1573-2568 |
| Popis: | The prevalence of coronary artery disease (CAD) is high among patients with cirrhosis; however, the impact of it on cardiovascular disease (CVD) is not known. The aim of the current study was to evaluate CVD events in patients with cirrhosis and impact of cirrhosis on biomarkers of atherogenesis. The study included 682 patients with decompensated cirrhosis referred for liver transplantation (LT) evaluation between 2010 and 2017. All patients were followed until they experienced a CVD event, non-cardiac death, liver transplantation or last follow-up. To evaluate mechanistic link, patients with NASH cirrhosis were propensity matched 1:2 to non-cirrhosis NASH patients and biomarkers of atherogenic risk were compared. The composite CVD outcome occurred in 23(3.4%) patients after a median follow-up period of 585 days (IQR 139, 747). A strong association between presence of any CAD and CVD event was noted (HR = 6.8, 95% CI 2.9, 15.9) that was independent of age, gender, BMI, and MELD score. In competing risk model, the combined rate of LT and non-cardiac was significantly higher when compared to the rate of CVD events. Marker of insulin resistance and inflammation-related markers were similar in patients with and without cirrhosis. Patients with cirrhosis were more likely to have reduced VLDL, sdLDL-C, LDL-C, and triglycerides. Interestingly, patients with cirrhosis had an increase in serum HDL-2, the anti-atherogenic lipoprotein, and adiponectin, a protective serum adipokine. The risk of CVD events in patients with cirrhosis is low and may potentially be due to improvement in markers of atherogenic risk. |
| Databáze: | OpenAIRE |
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