Clinical MRS Studies of the Brain
| Autor: | D. B. Twieg, H P Hetherington, B Hubesch, Michael W. Weiner, D S Marinier |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Magnetic Resonance Spectroscopy
Metabolite Central nervous system Phosphates Phosphocreatine Temporal lobe chemistry.chemical_compound Epilepsy Nuclear magnetic resonance medicine Humans Radiology Nuclear Medicine and imaging Stroke Brain Diseases medicine.diagnostic_test Brain Neoplasms business.industry Brain Phosphorus Magnetic resonance imaging General Medicine Hydrogen-Ion Concentration medicine.disease Hyperintensity medicine.anatomical_structure Epilepsy Temporal Lobe chemistry Protons Nuclear medicine business Hydrogen |
| Zdroj: | Investigative Radiology. 24:1039-1042 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/00004424-198912000-00026 |
| Popis: | Image-guided 31P and 1H magnetic resonance localized spectroscopy was performed on patients with brain tumors, temporal lobe epilepsy, chronic brain stroke, and deep white matter lesions. Absolute molar concentrations of metabolites, peak area ratios, and pH were obtained. The important findings were that 31P metabolite concentrations were significantly reduced in tumors, infarcts, and deep white matter lesions. Similarly, 1H metabolite intensities were reduced in chronic stroke. In the seizure foci of epilepsy patients, in tumors, and in chronic stroke, the pH was more alkaline than the normal pH. Peak area ratios were altered in tumors (reduction of phosphocreatine/inorganic phosphate (PCr/Pi) and in chronic stroke (large increases in Cr/NAA and Cho/NAA). Finally, the spectroscopic imaging technique offers a versatile alternative to the "single point" techniques, producing spectra or images of the spatial distribution of individual 31P metabolites. |
| Databáze: | OpenAIRE |
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