Highly Regio- and Enantioselective Reductive Coupling of Alkynes and Aldehydes via Photoredox Cobalt Dual Catalysis
| Autor: | Shi-Qi Zhang, Ji-Bao Xia, Yan-Lin Li, Jie Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Allylic rearrangement
Chemistry Chiral ligand Enantioselective synthesis chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Catalysis Coupling reaction 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Reagent Functional group Cobalt |
| Zdroj: | Journal of the American Chemical Society. 143:7306-7313 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | A Co-catalyzed highly regio- and enantioselective reductive coupling of alkynes and aldehydes has been developed under visible light photoredox dual catalysis. A variety of enantioenriched allylic alcohols have been obtained by using unsymmetrical internal alkynes and commercially available catalyst, chiral ligand, and reagents. It is noteworthy that this approach has considerable advantages, such as excellent regio- (>95:5 for >40 examples), stereo- (up to >95:5 E/Z), and enantioselectivity (92-99% ee, >35 examples) control, mild reaction conditions, broad substrate scope, and good functional group compatibility, making it a great improvement to enantioselective alkyne-aldehyde reductive coupling reactions. |
| Databáze: | OpenAIRE |
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