HLDF-6 peptide relieves symptoms of abstinence syndrome during experimental opium abuse
| Autor: | S. V. Litvinova, Leonid F. Panchenko, I. A. Kostanyan, V. V. Aristova, A. L. Kalyuzhnyi, N. N. Terebelina, V. V. Shul'govskii |
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| Rok vydání: | 2004 |
| Předmět: |
Male
media_common.quotation_subject Endogeny (+)-Naloxone Pharmacology General Biochemistry Genetics and Molecular Biology Neurochemical Medicine Animals Protease Inhibitors Rats Wistar media_common Brain Chemistry Behavior Animal business.industry Naloxone Brain Enkephalinase General Medicine Abstinence Neoplasm Proteins Rats Substance Withdrawal Syndrome Disease Models Animal Abstinence Syndrome Nociception Morphine Neprilysin business Morphine Dependence medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 137(5) |
| ISSN: | 0007-4888 |
| Popis: | Experiments were performed on rats with opium abuse induced by chronic administration of morphine in increasing doses. We studied the effect of HLDF-6 peptide on symptoms of naloxone abstinence. Repeated administration of HLDF-6 peptide in a dose of 0.2 mg/kg 24 and 0.5 h before naloxone relieved the major symptoms of the abstinence syndrome. A possible neurochemical mechanism underlying the effect of HLDF-6 peptide is inhibition of enkephalinase A in structures of the endogenous antinociceptive system. |
| Databáze: | OpenAIRE |
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