Healing activity induced by Cramoll 1,4 lectin in healthy and immunocompromised mice
| Autor: | Maria Tereza dos Santos Correia, Ana Lúcia Figueiredo Porto, Carmelita C. Bezerra Cavalcanti, Ana Maria dos Anjos Carneiro Leão, Camila Souza Porto, Luana Cassandra Breitenbach Barroso Coelho, Mario Ribeiro de Melo-Júnior, Cristiane Moutinho Lagos de Melo, Chirleanny Maciel Mendes |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pathology
medicine.medical_specialty Neutrophils medicine.medical_treatment Scar tissue Pharmaceutical Science Wounds Penetrating Immunocompromised Host Mice Collagen fiber Edema Cratylia mollis Animals Medicine Immunocompromised Skin Wound Healing biology integumentary system business.industry Wound Lectin Granulation tissue Fabaceae Surgical wound Disease Models Animal medicine.anatomical_structure Cytokine Neutrophil Infiltration Seeds Immunology biology.protein Female Plant Lectins medicine.symptom business |
| Zdroj: | International Journal of Pharmaceutics. (1-2):113-119 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2011.02.011 |
| Popis: | Cramoll 1,4 is a lectin extracted from seeds of Cratylia mollis Mart. Many assays have shown the cytokine release activity and pro-inflammatory profile of this lectin. Here, we used Cramoll 1,4 in the treatment of cutaneous wounds in normal and immunocompromised mice for available your cicatricial power. Surgical wounds were treated daily with a topical administration of Cramoll 1,4 and parameters as edema, hyperemia, scab, granulation and scar tissues as well as contraction of wounds were analyzed. Cramoll 1,4 wounds showed higher edema and arrival of more polimorphonuclear cells at the site of lesions. Granulation tissue and collagen fiber deposition were observed with higher intensity in all Cramoll 1,4 treated wounds and promoted excellent closing and repair of lesions in less time than other groups. Results showed that Cramoll 1,4 lectin was effective in the repair of experimental lesions in mice and can be used as a future cicatricial compound. |
| Databáze: | OpenAIRE |
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