Improving the Sensitivity of FESTA Methods for the Analysis of Fluorinated Mixtures

Autor:	Gareth A. Morris, Thaís M. Barbosa, Laura Castañar, Roberto Rittner, Cláudio F. Tormena, Pinelopi Moutzouri, Mathias Nilsson
Rok vydání:	2019
Předmět:	NMR spectra database Chemistry Spin echo Nuclear magnetic resonance spectroscopy Sensitivity (control systems) Biological system Excitation Analytical Chemistry Spin-½ Spectral purity
Zdroj:	Analytical Chemistry. 92:2224-2228
ISSN:	1520-6882 0003-2700
DOI:	10.1021/acs.analchem.9b04924
Popis:	The analysis of complex mixtures is an important but often intractable problem. When species contain sparse fluorine atoms, NMR spectra of fluorine-containing spin systems can be efficiently extracted from an intact mixture using the recently proposed FESTA (Fluorine-Edited Selective TOCSY Acquisition) methodology. Here an alternative approach to the existing selective reverse INEPT FESTA (SRI-FESTA) experiment is described, based on the use of a modulated spin echo for the initial excitation. MODO-FESTA (modulated echo FESTA) is simpler and has a significant sensitivity advantage over SRI-FESTA. Comparisons are presented of the relative sensitivity and spectral purity of the two types of methods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2821db0abd5cc5c55b68d6b2140f3192 https://doi.org/10.1021/acs.analchem.9b04924 Zobrazit plný text záznamu