Tolerance of intraperitoneal chemohyperthermia with mitomycin C: in vivo study in dogs
| Autor: | Carry Py, A. Rochette, G. Braillon, M. Manchon, François-Noël Gilly, J. Baulieux, A. C. Sayag, G. Panteix, J. L. Peix, James I |
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| Rok vydání: | 1992 |
| Předmět: |
Hyperthermia
Cancer Research medicine.medical_specialty Physiology medicine.medical_treatment Mitomycin Anastomosis Beagle Gastroenterology Peritoneal cavity Dogs In vivo Physiology (medical) Internal medicine medicine Animals Peritoneal Lavage Peritoneal Neoplasms Chemotherapy business.industry Mitomycin C Drug Tolerance Hyperthermia Induced medicine.disease Combined Modality Therapy medicine.anatomical_structure Liver Evaluation Studies as Topic Anesthesia Toxicity business |
| Zdroj: | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 8(5) |
| ISSN: | 0265-6736 |
| Popis: | Tolerance of intraperitoneal chemohyperthermia (IPCH) with mitomycin C (2 mg/kg) by irrigation of the peritoneal cavity via a closed circuit system was evaluated in Beagle dogs for possible use in the management of human peritoneal carcinomatosis. Of dogs, 24 underwent three digestive anastomoses each. They were randomized into three groups: control (n = 6), intraperitoneal hyperthermia (n = 8) and IPCH (n = 10). Peritoneal temperatures were maintained between 41-43 degrees C for 60 min. Tolerance was evaluated through clinical follow-up, biological samples (serum electrolytes, blood counts and serum enzymes), histological examinations and post-mortem macro- and microscopic controls of anastomosis. Mortality and morbidity rates were not different in the three groups. No anastomotic leakage occurred. Evidence of biological toxicity was minimal. Histological examinations showed no definitive tissue damage. IPCH appears to be a safe and reliable device in dogs. Plans to combine IPCH with MMC in surgical resection of patients with peritoneal carcinomatosis are underway. |
| Databáze: | OpenAIRE |
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