Additional weight load increases freezing of gait episodes in Parkinson’s disease; an experimental study
| Autor: | Jacques Duysens, Lars B. Oude Nijhuis, Bastiaan R. Bloem, Geert E. A. van Bon, Senja H. G. Mensink, A.H. Snijders, Jorik Nonnekes, Vivian Weerdesteyn |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Future studies Parkinson's disease Neurology Pilot Projects Kinematics medicine.disease_cause Weight-bearing Weight-Bearing Gait (human) Physical medicine and rehabilitation medicine Humans Ground reaction force Lead (electronics) Gait Gait Disorders Neurologic Aged Parkinson Disease Middle Aged Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] medicine.disease Physical therapy Female Neurology (clinical) Psychology human activities |
| Zdroj: | Journal of Neurology, 261, 999-1008 Journal of Neurology, 261, 5, pp. 999-1008 |
| ISSN: | 1432-1459 0340-5354 |
| Popis: | Freezing of gait is an episodic gait disorder, characterized by the inability to generate effective forward stepping movements. The pathophysiology underlying freezing of gait remains insufficiently understood, and this hampers the development of better treatment strategies. Preliminary evidence suggests that impaired force control during walking may contribute to freezing episodes, with difficulty to unload the swing leg and initiate the swing phase. Here, we used external loading to manipulate force control and to investigate its influence on freezing of gait. Twelve Parkinson’s disease patients with freezing of gait performed three contrasting tasks: (1) loaded gait while wearing a belt fortified with lead weights; (2) weight-supported gait using a parachute harness connected to a rigid metal cable running above the gait trajectory; and (3) normal gait. Gait tasks were used to provoke freezing episodes, including rapid 360° turns. Freezing episodes were quantified using blinded, videotaped clinical assessment. Furthermore, ground reaction forces and body kinematics were recorded. Loading significantly increased the mean number of freezing episodes per trial compared to the normal gait condition (P |
| Databáze: | OpenAIRE |
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