Beneficial Effects of Adaptive Servo Ventilation in Patients With Chronic Heart Failure
| Autor: | Toshimitsu Kosaka, Yusuke Kobukai, Hiroyuki Watanabe, Hiroshi Ito, Yoshiko Munehisa, Takashi Koyama, Shin Makabe, Kenji Iino |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty animal structures Polysomnography Positive-Pressure Respiration Sleep Apnea Syndromes Internal medicine Natriuretic Peptide Brain Humans Medicine cardiovascular diseases Aged Heart Failure Inflammation Ejection fraction biology medicine.diagnostic_test business.industry C-reactive protein General Medicine Middle Aged medicine.disease Brain natriuretic peptide C-Reactive Protein Treatment Outcome Apnea–hypopnea index Anesthesia Heart failure Chronic Disease embryonic structures biology.protein Breathing Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Journal. 74:2118-2124 |
| ISSN: | 1347-4820 1346-9843 2118-2124 |
| Popis: | Background: Sleep-disordered breathing (SDB) is thought to be a state of inflammation caused by hypoxic stress. Whether adaptive servo ventilation (ASV) attenuates the inflammatory response and improves the cardiac function of patients with congestive heart failure (CHF) accompanied by SDB was not been investigated. Methods and Results: Seventeen inpatients with New York Heart Association (NYHA) II or III underwent polysomnography. There was a positive correlation between the apnea hypopnea index and high-sensitivity C-reactive protein (hs-CRP) level (r=0.753, P=0.016). The patients were divided into ASV (n=10) and non-ASV groups (n=7), and CHF-parameters were measured before and after ASV treatment. Improvement was noted for the NYHA class in the ASV group but not in the non-ASV group. In contrast to the non-ASV group, the level of brain natriuretic peptide (BNP), ejection fraction, and hs-CRP levels in the ASV group significantly improved (BNP, 212.1±181.2 to 77.3±54.0 pg/ml [P |
| Databáze: | OpenAIRE |
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