Swedish lung cancer radiation study group: the prognostic value of anaemia, thrombocytosis and leukocytosis at time of diagnosis in patients with non-small cell lung cancer
| Autor: | Signe Friesland, Martin Helsing, Kristina Lamberg Lundström, Margareta Holgersson, Elisabet Birath, Simon Ekman, Charlotte Mörth, Christer Janson, Even Hoye, Roger Henriksson, Thomas Blystad, Britta Lödén, Michael Bergqvist, Georg Holgersson, Jan Nyman, Stefan Bergström, Martin Sandelin, Sven-Börje Ewers |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms Leukocytosis medicine.medical_treatment Kaplan-Meier Estimate Gastroenterology Risk Factors Carcinoma Non-Small-Cell Lung Internal medicine White blood cell Carcinoma medicine Humans Lung cancer Aged Neoplasm Staging Proportional Hazards Models Sweden Thrombocytosis Hematology Proportional hazards model business.industry Anemia General Medicine Middle Aged Prognosis medicine.disease Surgery Radiation therapy medicine.anatomical_structure Oncology Female medicine.symptom business |
| Zdroj: | Medical Oncology. 29:3176-3182 |
| ISSN: | 1559-131X 1357-0560 |
| Popis: | There is a need to improve the prognostic and predictive indicators in non-small cell lung cancer (NSCLC). At present, the main focus is on genetic predictive markers while the prognostic value of the standard blood variables related to haematopoiesis has been subjected to relatively limited attention. To study the prognostic potential of haemoglobin (Hgb), platelet (Plt) and white blood cell (WBC) levels at time of diagnosis in NSCLC patients, 835 NSCLC patients, stage I-IV, who received radiotherapy with curative intention (50 Gy), were included in the study. WBC, Plt, Hgb, gender, age at diagnosis, stage, surgery and first-line chemotherapy were studied in relation to overall survival. For patients with Hgb110 g/L and Hgb ≥ 110 g/L), the median survival was 11.2 and 14.5 months, respectively (p = 0.0032). For WBC9.0 × 10(9)/L and9.0 × 10(9)/L, the median survival was 11.6 and 15.4 months, respectively (p0.0001). For Plt350 × 10(9)/L and350 × 10(9)/L, the median survival was 11.2 and 14.9 months, respectively (p0.0001). The median survival in patients with pathological results in all three markers was half of that in patients with normal levels of all three markers (8.0 and 16.0 months, respectively (p0.0001). The level of the three studied haematological biomarkers corresponds significantly to outcome in NSCLC. These results indicate that standard haematological variables may be used as guidance for the clinician in the decision-making regarding treatment intensity and patient information. |
| Databáze: | OpenAIRE |
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