ACTIVATION OF HUMAN FIBROBLASTS BY CHRONIC RADIATION RATHER THAN ACUTE RADIATION

Autor:	T Shimura, E Zaharieva, M Sasatani, H Kawai, K Kamiya, A Ushiyama
Rok vydání:	2022
Předmět:	Radiation Cancer-Associated Fibroblasts Radiological and Ultrasound Technology Neoplasms Tumor Microenvironment Public Health Environmental and Occupational Health Humans Radiology Nuclear Medicine and imaging General Medicine Fibroblasts Reactive Oxygen Species
Zdroj:	Radiation Protection Dosimetry. 198:1098-1103
ISSN:	1742-3406 0144-8420
DOI:	10.1093/rpd/ncac065
Popis:	Cancer-associated fibroblast (CAF), an activated type of fibroblast, is a major stromal cell that contributes to tumor initiation and development in the tumor microenvironment (TME). We previously reported that fractionated radiation rather than acute radiation causes progressive damage to mitochondria and increases the generation of reactive oxygen species, playing an important role in the fibroblast activation in normal tissue injury. Activated fibroblasts then become CAF by interacting with tumor cells, promoting tumor growth in vivo. We here examined the chronic radiation effect on fibroblast activation. Acute radiation (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281e2aaa41509c774d3a26adbcd804c6 https://doi.org/10.1093/rpd/ncac065 Zobrazit plný text záznamu