Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning
Autor: | Lydia González, Javier D. Martín-Romera, Purificación Sánchez-Sánchez, Jorge A. R. Navarro, Elisa Barea, Carmen R. Maldonado, Francisco J. Carmona |
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Rok vydání: | 2023 |
Předmět: | |
Zdroj: | Inorganic Chemistry. 62:5049-5053 |
ISSN: | 1520-510X 0020-1669 |
Popis: | A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t1/2 = 183 min; 95% removal rate after 24 h). MCIN/AEI PID2020-113608RB-I00 FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades P20_00672 P18-RT-612 University of Granada PPJIA2021.20 Marie Sklodowska-Curie Individual Fellowship within the European Union H2020 programme H2020-MSCA-IF-2019-EF-ST-888972-PSustMOF the European Union H2020 EU FEDER Garantía Juvenil en I+D+i, PEJ2018-004022-A Universidad de Granada/CBUA Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente” (University of Granada). |
Databáze: | OpenAIRE |
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