Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning

Autor: Lydia González, Javier D. Martín-Romera, Purificación Sánchez-Sánchez, Jorge A. R. Navarro, Elisa Barea, Carmen R. Maldonado, Francisco J. Carmona
Rok vydání: 2023
Předmět:
Zdroj: Inorganic Chemistry. 62:5049-5053
ISSN: 1520-510X
0020-1669
Popis: A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t1/2 = 183 min; 95% removal rate after 24 h).
MCIN/AEI PID2020-113608RB-I00
FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades P20_00672 P18-RT-612
University of Granada PPJIA2021.20
Marie Sklodowska-Curie Individual Fellowship within the European Union H2020 programme H2020-MSCA-IF-2019-EF-ST-888972-PSustMOF
the European Union H2020
EU FEDER
Garantía Juvenil en I+D+i, PEJ2018-004022-A
Universidad de Granada/CBUA
Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente” (University of Granada).
Databáze: OpenAIRE