Primary Amebic Meningoencephalitis in Children: A Report of Two Fatal Cases and Review of the Literature
| Autor: | Katie E. Friederich, Michael A. Lopez, Varina L. Boerwinkle, Davut Pehlivan, Robert C. Stowe, Shannon DiCarlo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty Adolescent 030106 microbiology Central Nervous System Protozoal Infections Status epilepticus 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Developmental Neuroscience 030225 pediatrics medicine Humans Naegleria fowleri Intracranial pressure Miltefosine biology business.industry Meningoencephalitis Electroencephalography medicine.disease biology.organism_classification Magnetic Resonance Imaging Surgery Neurology Child Preschool Pediatrics Perinatology and Child Health Neurology (clinical) medicine.symptom business Neurocognitive Meningitis medicine.drug |
| Zdroj: | Pediatric neurology. 70 |
| ISSN: | 1873-5150 |
| Popis: | Background Primary amebic meningoencephalitis is a rare, almost uniformly fatal disease of cerebral invasion by Naegleria fowleri , occurring most commonly after swimming in warm fresh water in summer months. Treatment using the experimental medication miltefosine demonstrated improved survival and favorable neurocognitive outcome in a 2013 North American patient. There is little information about the electroencephalographic findings of such patients, and our understanding of factors predicting survival is limited. Methods and Results We describe two children, aged four and 14 years, who both presented with seizures and altered mental status after recent fresh water swimming exposures. With evidence of pyogenic meningitis and examination of cerebrospinal fluid demonstrating motile trophozoites on wet mount, N. fowleri meningoencephalitis was diagnosed. Amebicidal antibiotic regimens with miltefosine were administered. Continuous electroencephalography monitoring demonstrated evolution from diffuse slowing to seizures, status epilepticus, and eventually global attenuation and absence of activity. Both patients ultimately died after complications of progressive increasing intracranial pressure and hemodynamic compromise. Conclusions Primary amebic meningoencephalitis is a serious, sporadic infection. We describe two fatal pediatric patients, the evolution of their electroencephalography findings, and compare their findings with the 13 reported pediatric survivors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect