Protein Tyrosine Phosphatase 1B (PTP1B)-Inhibiting Constituents from the Leaves of Syzygium polyanthum
| Autor: | Shigetoshi Kadota, Ken Tanaka, Azis Saifudin, Yasuhiro Tezuka |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Syzygium
Pharmaceutical Science Positive control Protein tyrosine phosphatase Analytical Chemistry Inhibitory Concentration 50 Drug Discovery Benzene Derivatives Humans Inhibitory concentration 50 Enzyme Inhibitors Protein Tyrosine Phosphatase Non-Receptor Type 1 Pharmacology Molecular Structure biology Traditional medicine Plant Extracts Organic Chemistry Myrtaceae biology.organism_classification Protein Tyrosine Phosphatase 1B Plant Leaves Inhibitory potency Complementary and alternative medicine Biochemistry Molecular Medicine |
| Zdroj: | Planta Medica. 78:1378-1381 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | A methanol extract of the leaves of Syzygium polyanthum (Wight) Walp. afforded four new acylbenzene derivatives (1-4) together with seven known compounds (5-11). The structures of 1-11 were elucidated by extensive spectroscopic methods and comparison with the literature data. The new compounds 1-3 and a known compound, campest-4-en-3-one (10), exhibited a significant protein tyrosine phosphatase 1B inhibitory activity with IC₅₀ values of 13.1 ± 0.1, 5.77 ± 0.15, 4.01 ± 0.26, and 10.4 ± 0.5 µM, respectively. The inhibitory potency of the new compounds 2 and 3 was comparable to that of a positive control RK-682 (IC₅₀, 5.51 ± 0.04 µM). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|