Novel Protein Glycan–Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion

Autor: Agustín Escalante, Carlos Lorenzo, Steven M. Haffner, Marian Rewers, Andreas Festa, Anthony J. Hanley
Rok vydání: 2016
Předmět:
Blood Glucose
Male
0301 basic medicine
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Galactosamine
Inflammation
Type 2 diabetes
030204 cardiovascular system & hematology
Systemic inflammation
Acetylglucosamine
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Polysaccharides
Diabetes mellitus
Internal medicine
Insulin Secretion
Internal Medicine
medicine
Humans
Insulin
Pathophysiology/Complications
Advanced and Specialized Nursing
Glucose tolerance test
medicine.diagnostic_test
biology
business.industry
C-reactive protein
Glucose Tolerance Test
Middle Aged
medicine.disease
C-Reactive Protein
Cross-Sectional Studies
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
Linear Models
biology.protein
Female
Insulin Resistance
medicine.symptom
business
Biomarkers
Zdroj: Diabetes Care
ISSN: 1935-5548
0149-5992
DOI: 10.2337/dc16-1569
Popis: OBJECTIVE N-acetylglucosamine/galactosamine (GlycA) and sialic acid (GlycB) moieties of glycosylated serum proteins are nonspecific measures of inflammation, but conclusive data on their relationship with insulin resistance or insulin secretion are missing. Therefore, we aimed to examine the relation of GlycA, GlycB, and C-reactive protein (CRP) to direct measures of insulin sensitivity (insulin sensitivity index [SI]) and insulin secretion (acute insulin response [AIR]). RESEARCH DESIGN AND METHODS This study used cross-sectional analyses and included 1,225 participants with and without type 2 diabetes in the Insulin Resistance Atherosclerosis Study (IRAS). SI and AIR were measured using the frequently sampled intravenous glucose tolerance test, and GlycA and GlycB were measured using nuclear magnetic resonance spectroscopy. RESULTS GlycA and GlycB had a strong correlation with CRP (r = 0.60 [P < 0.001] and r = 0.46 [P < 0.001], respectively). In a linear regression model with both GlycA and CRP as independent variables, GlycA (β × 1 SD, −0.04 ± 0.02; P < 0.01) and CRP (−0.06 ± 0.02; P < 0.001) were independently associated with SI even after adjusting for demographics, smoking, physical activity, plasma glucose, and BMI. However, neither CRP nor GlycA had an independent relationship with AIR. CONCLUSIONS GlycA may complement CRP in evaluating the relationship between inflammation, glucose tolerance, and insulin resistance.
Databáze: OpenAIRE
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