Lithium response in bipolar disorder: No difference in GADL1 gene expression between cell lines from excellent-responders and non-responders
| Autor: | Jeverson Moreira, Frank Bellivier, Marie-Claire Cynthia, Emmanuel Curis, Pierre A. Geoffroy, Cindie Courtin |
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| Přispěvatelé: | Optimisation Thérapeutique en Neuropsychopharmacologie (VariaPsy - U1144), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Université Sorbonne Paris Cité (USPC), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Fondation FondaMental [Créteil], Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) (SBIM), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut national du cancer [Boulogne] (INCA)-CHU Saint Louis [APHP], Université Paris Descartes - Faculté de Pharmacie de Paris (UPD5 Pharmacie), Université Paris Descartes - Paris 5 (UPD5), Variabilité de réponse aux Psychotropes (VariaPsy - U1144), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut national du cancer [Boulogne] (INCA)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Bipolar Disorder Lithium (medication) Carboxy-Lyases Glutamate decarboxylase Gene Expression Cell Line 03 medical and health sciences 0302 clinical medicine Antimanic Agents Internal medicine [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Humans Medicine Bipolar disorder Biological Psychiatry ComputingMilieux_MISCELLANEOUS Genetic association Polymorphism Genetic business.industry Lymphoblast Middle Aged medicine.disease Psychiatry and Mental health Treatment Outcome 030104 developmental biology Endocrinology Cell culture Lithium Compounds Biomarker (medicine) Female Gene polymorphism business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychiatry Research Psychiatry Research, Elsevier, 2017, 251, pp.217-220. ⟨10.1016/j.psychres.2017.02.022⟩ |
| ISSN: | 0165-1781 1872-7123 |
| Popis: | Previous association studies have shown mixed results between glutamic acid decarboxylase like-1 (GADL1) gene polymorphism and prophylactic lithium response in bipolar disorder (BD) patients. In the present study, GADL1 gene expression was investigated in regard to lithium response, using Alda scale, in lymphoblastoid cells (LCLs) of 36 Caucasian BD patients. No difference in GADL1 expression was observed among LCLs from excellent-responders, non-responders or controls. Furthermore, lithium did not induce significant changes in GADL1 expression levels after 4 or 8 days. These results did not support an association of GADL1 expression in the determination of a lithium response in BD patients. |
| Databáze: | OpenAIRE |
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