The effect of treating with anti-interleukin-1 receptor antibody on the course of experimental murine cutaneous leishmaniasis
| Autor: | Anuraj H. Shankar, Andrew L. Glasebrook, Cynthia M. Theodos, William D. Roeder, Richard G. Titus |
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| Rok vydání: | 1994 |
| Předmět: |
T cell
Immunology Leishmaniasis Cutaneous Interleukin-1 receptor Lymphocyte Activation Parasitemia Mice Cutaneous leishmaniasis medicine Animals Leishmania major B cell Mice Inbred BALB C biology Interleukin Antibodies Monoclonal Receptors Interleukin-1 Leishmaniasis biology.organism_classification medicine.disease Leishmania Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Cytokines Parasitology Lymph Nodes Interleukin-1 |
| Zdroj: | Parasite immunology. 16(11) |
| ISSN: | 0141-9838 |
| Popis: | To assess the role of interleukin-1 (IL-1) in cutaneous leishmaniasis, Leishmania major-infected mice were treated with an anti-IL-1 receptor monoclonal antibody, LA-15.6. MoAb LA-15.6 prevents binding of IL-1 to both the T cell and B cell/macrophage forms of the IL-1 receptor. We found that treating with LA 15.6 inhibited the development of cutaneous lesions of L. major in both genetically-susceptible and resistant mice. Interestingly, this treatment had little or no effect on parasite numbers in the lesions or on the cytokines (interferon-gamma, interleukin-4) that the animals produced in response to infection with the parasite. These results suggest that although IL-1 plays a detrimental role in cutaneous leishmaniasis, it does not mediate this effect by altering the parasite-specific T cell response. |
| Databáze: | OpenAIRE |
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