Administration of Atrial Natriuretic Peptide Attenuates Reperfusion Phenomena and Preserves Left Ventricular Regional Wall Motion After Direct Coronary Angioplasty for Acute Myocardial Infarction
| Autor: | Toshiyasu Hoshi, Hiroyasu Sugimura, Isao Taguchi, Hideyo Kuga, Masatoshi Nakatsugawa, Akitugu Oida, Shichirou Abe, Kenichi Ogawa, Noboru Kaneko |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Heart disease medicine.medical_treatment Myocardial Infarction Blood Pressure Myocardial Reperfusion Injury Ventricular tachycardia Ventricular Function Left Atrial natriuretic peptide Coronary Circulation Angioplasty Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Angioplasty Balloon Coronary Ventricular remodeling Fibrillation Ejection fraction business.industry General Medicine Middle Aged medicine.disease Myocardial Contraction Ventricular Fibrillation cardiovascular system Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor |
| Zdroj: | Circulation Journal. 67:443-448 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | To evaluate the effects of synthetic human atrial natriuretic peptide (hANP) on myocardial reperfusion injury and left ventricular remodeling, 19 patients within 12 h of a first attack of anterior myocardial infarction (AMI) underwent intracoronary injection of 25 μg of hANP immediately after coronary angioplasty, combined with intravenous infusion of 0.025 μg · kg-1 · min-1 of hANP initiated on admission for 1 week (hANP group); 18 similar patients had saline administered (control group). The incidences of premature ventricular contraction, ventricular tachycardia and/or fibrillation in the hANP group were significantly less than in the control group after coronary angioplasty. Left ventricular ejection fraction was significantly greater and left ventricular end-diastolic volume index was significantly smaller 6 months after coronary angioplasty. Left ventricular regional wall motion of the infarcted segments significantly increased. Thus, hANP remarkably suppressed reperfusion phenomena and preserved left ventricular function through improvement of regional wall motion of the infarcted segments after coronary angioplasty. (Circ J 2003; 67: 443 - 448) |
| Databáze: | OpenAIRE |
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