The microvascular thrombi of colonic tissue in ulcerative colitis
| Autor: | Jingguo Zhou, Qin Ouyang, Guobin He, Feng-yuan Li, Daiyun Chen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Physiology Colon Biopsy Risk Factors Internal medicine medicine Humans medicine.diagnostic_test business.industry Vascular disease Microcirculation Gastroenterology Integrin beta3 Histology Thrombosis Heparin Hepatology Middle Aged medicine.disease Prognosis Ulcerative colitis Immunohistochemistry Regression Analysis Colitis Ulcerative Female business Azo Compounds medicine.drug Follow-Up Studies |
| Zdroj: | Digestive diseases and sciences. 52(9) |
| ISSN: | 0163-2116 |
| Popis: | Mucosal microvascular thrombi in rectal biopsies were observed in some ulcerative colitis (UC). Heparin may be effective in steroid resistant UC in some studies, however, the new results of meta-analysis demonstrated a non-significant effect of heparin in controlled clinical trials, differing markedly from observational studies. The objective of this study was to identify colonic microvascular thrombi in larger cases with UC, and analyse its possible risk factors: age, gender, histologic score, extent of lesions and operation or biopsy specimens, and assess the significance of microvascular thrombosis in patients with UC. The microvascular thrombi were identified by immunohistochemical staining with anti-CD61 monoclonal antibody and Martius scarlet blue (MSB) staining in 40 colonic tissue samples of UC (31 biopsy specimens and nine operated cases) and 12 cases of normal colon tissue from operated colonic carcinoma. Logistic regression analysis was used to assess the relationship of age, gender, degree of histology, origin of the specimens, extent of lesions and microvascular thrombi examined. Microvascular thrombi were positive in 14 of 40 UC cases, and none in the controls. The presence of microvascular thrombi was related to operation specimens with odds ratio 11.667, P=0.0179, it might be also related to histologic score (OR=1.350) and extent of lesions (OR=1.619). These results suggest that microvascular thrombosis may be one of the important pathogenesis in some UC, and that the effect of anticoagulant treatment still needs to be assessed. |
| Databáze: | OpenAIRE |
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