Cerebral Pathology in Immunodeficient Gnotobiotic Laboratory Mice
| Autor: | Piotr Sura, Zbigniew Srebro |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Endogeny Mice SCID Biology General Biochemistry Genetics and Molecular Biology Benign tumor Muscle hypertrophy hemosiderin Mice Pineal gland medicine Animals Germ-Free Life Meningitis Cerebrum Mice Inbred BALB C meningitis General Medicine medicine.disease Hydrocephalus medicine.anatomical_structure knockout mice brain Hemosiderin Immunology Knockout mouse Pia Mater hydrocephalus |
| Zdroj: | Folia Biologica. 53:205-208 |
| ISSN: | 0015-5497 |
| DOI: | 10.3409/173491605775142738 |
| Popis: | Gnotobiotic autoimmunity prone, antigen presentation, T lymphocyte receptor gene knockout mice show cerebral pathology in the form of meningitis, venous blood statis with subarachnoid hemorrhages and massive hemosiderin deposits. A more or less severe hydrocephalus was present in all animals examined. In all cases except the CD 1(-/-) animals, the pineal gland was considerably reduced in mass. Only in the latter strain was a strong pineal hypertrophy in the form of a benign tumor present in ca. 50% of the animals. A possible sequence of events leading to hydrocephalus is discussed. Endogenous vertically transmitted facultative pathogens, active in the immunocompromised animals, probably play a primary etiological role. The results show that caution is needed in planning immunobiological studies on the B10.PL and B10.PL-derived mice, and possibly other strains not examined for possible neuropathological changes. |
| Databáze: | OpenAIRE |
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