Stress-induced resistance to the fear memory labilization/reconsolidation process. Involvement of the basolateral amygdala complex
| Autor: | Pablo Javier Espejo, Victor A. Molina, Vanesa Ortiz, Irene Delia Martijena |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Farmacología y Farmacia medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Allosteric modulator Midazolam Stress Receptors N-Methyl-D-Aspartate Partial agonist Amygdala Random Allocation 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine Zif-268 medicine Animals Rats Wistar Receptor Early Growth Response Protein 1 Memory Consolidation Pharmacology Basolateral Nuclear Complex Chemistry Cycloserine Reconsolidation Fear Rats 030227 psychiatry Medicina Básica medicine.anatomical_structure Endocrinology Anesthesia NMDA receptor Memory consolidation D-Cycloserine Stress Psychological 030217 neurology & neurosurgery Glun2b Basolateral amygdala medicine.drug |
| Zdroj: | Neuropharmacology. 109:349-356 |
| ISSN: | 0028-3908 |
| Popis: | Consolidated memories can enter into a labile state after reactivation followed by a restabilization process defined as reconsolidation. This process can be interfered with Midazolam (MDZ), a positive allosteric modulator of the GABA-A receptor. The present study has evaluated the influence of prior stress on MDZ's interfering effect. We also assessed the influence of both systemic and intra-basolateral amygdala (BLA) infusion of D-cycloserine (DCS), a partial agonist of the NMDA receptors, on the MDZ effect in previously stressed rats. Furthermore, we analyzed the effect of stress on the expression of Zif-268 and the GluN2B sites, two molecular markers of the labilization/reconsolidation process, following reactivation. The results revealed that prior stress resulted into a memory trace that was insensitive to the MDZ impairing effect. Both systemic and intra-BLA DCS administration previous to reactivation restored MDZ's disruptive effect on memory reconsolidation in stressed animals. Further, reactivation enhanced Zif-268 expression in the BLA in control unstressed rats, whereas no elevation was observed in stressed animals. In agreement with the behavioral findings, DCS restored the increased level of Zif-268 expression in the BLA in stressed animals. Moreover, memory reactivation in unstressed animals elevated GluN2B expression in the BLA, thus suggesting that this effect is involved in memory destabilization, whereas stressed animals did not reveal any changes. These findings are consistent with resistance to the MDZ effect in these rats, indicating that stress exposure prevents the onset of destabilization following reactivation. In summary, prior stress limited both the occurrence of the reactivation-induced destabilization and restabilization. Fil: Espejo, Pablo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Ortiz, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Martijena, Irene Delia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Molina, Víctor Alejandro. Universidad Nacional de Córdoba; Argentina |
| Databáze: | OpenAIRE |
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