Potential of using boric acid as a boron drug for boron neutron capture therapy for osteosarcoma
| Autor: | Y.C. Lin, Sy-Yu Lin, C.F. Hsu, Fong-In Chou, Jinn-Jer Peir, Jiunn-Wang Liao |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
inorganic chemicals
Male Biodistribution chemistry.chemical_element Bone Neoplasms Boron Neutron Capture Therapy Boric acid Rats Sprague-Dawley chemistry.chemical_compound Pharmacokinetics Boric Acids Cell Line Tumor medicine Animals Tissue Distribution Cytotoxicity Boron Osteosarcoma Radiation Chemistry Bone cancer Radiochemistry medicine.disease Rats Cancer cell |
| Zdroj: | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 69(12) |
| ISSN: | 1872-9800 |
| Popis: | Osteosarcoma is a malignant tumor commonly found in human and animals. The ability of boric acid (BA) to accumulate in osteosarcoma due to the mechanism of the bone formation of cancer cells would make boron neutron capture therapy (BNCT) an alternative therapy for osteosarcoma. This study evaluated the feasibility of using BA as the boron drug for BNCT of bone cancer. The cytotoxicity of BA to L929 cells exceeded that of UMR-106 cells. With 25 μg 10B/mL medium of BA treatment, the boron concentration in UMR-106 cells was higher than that in L929 cells. The biodistribution and pharmacokinetics of BA in Sprague–Dawley (SD) rats were studied by administrating 25 mg 10B/kg body weight to SD rats. Blood boron level decreased rapidly within one hour after BA injection. Boron concentration in the long bone was 4–6 time higher than that of blood. Results of this study suggest that BA may be a potential drug for BNCT for osteosarcoma. |
| Databáze: | OpenAIRE |
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