Effect of free thymol on differential gene expression in gastric mucosa of the young pig
| Autor: | Paolo Trevisi, Mario P. Colombo, Maria Nieddu, Greta Gandolfi, Paolo Bosi, Davide Priori, Gianpiero Boatto |
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| Přispěvatelé: | M. Colombo, D. Priori, G. Gandolfi, G. Boatto, M. Nieddu, P. Bosi, P. Trevisi |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
pig Swine stomaco Weaning SF1-1100 chemistry.chemical_compound Anti-Infective Agents thymol Gene expression Gastric mucosa medicine espressione genica Animals Receptor Thymol Regulation of gene expression biology Stomach Peptide transporter 1 suino timolo Anatomy Molecular biology Animal culture Calcium Dietary medicine.anatomical_structure chemistry Gene Expression Regulation Gastric Mucosa Dietary Supplements biology.protein gene expression Animal Science and Zoology Digestion stomach |
| Zdroj: | Animal, Vol 8, Iss 5, Pp 786-791 (2014) |
| ISSN: | 1751-7311 |
| Popis: | Thymol is the most common molecule in thyme and has been proposed as an oral alternative to antibiotics in the feed of pigs and broilers. The knowledge of the in vivo physiological effects of thymol on tissues is limited, particularly its impact on the gastric mucosa, where it is primarily absorbed when it is orally supplied. In this study, thymol (TH, 50 mg/ kg BW) or a placebo (CO) was introduced directly into the stomach of 8 weaned pigs that were slaughtered 12 h later and sampled for gastric oxyntic and pyloric mucosa. The analysis of whole transcript expression was performed using Affymetrix© Porcine Gene 1.1 ST array strips. Affymetrix Transcripts IDs were associated with 13 406 human gene names based on Sus scrofa Ensemble. Gene Set Enrichment Analysis was performed, comparing TH and CO pigs. For each gene set, the normalized enrichment score (NES) was defined as significant when the false discovery rate % was |
| Databáze: | OpenAIRE |
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