Pregnancy associated plasma protein-A (PAPP-A) is not a marker of the vulnerable atherosclerotic plaque
| Autor: | Karen Ege Olsen, Kasper Iversen, Børge Teisner, Ane S. Teisner, Søren Dalager, Charlotte Floridon |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Acute coronary syndrome Pathology medicine.medical_specialty Pregnancy-associated plasma protein A medicine.drug_class Clinical Biochemistry Myocardial Infarction Ischemia medicine.disease_cause medicine Humans Pregnancy-Associated Plasma Protein-A False Positive Reactions Myocardial infarction Acute Coronary Syndrome Diagnostic Errors Aged Heparin business.industry Vascular disease Anticoagulant General Medicine Atherosclerosis medicine.disease Immunohistochemistry Vulnerable plaque Plaque Atherosclerotic Biological Markers Female business Biomarkers medicine.drug |
| Zdroj: | Iversen, K, Teisner, A, Dalager, S, Olsen, K E, Floridon, C & Teisner, B 2011, ' Pregnancy associated plasma protein-A (PAPP-A) is not a marker of the vulnerable atherosclerotic plaque ', Clinical Biochemistry, vol. 44, no. 4, pp. 312-318 . https://doi.org/10.1016/j.clinbiochem.2010.12.010 Iversen, K K, Teisner, A S, Dalager, S, Olsen, K E, Floridon, C & Teisner, B 2011, ' Pregnancy associated plasma protein-A (PAPP-A) is not a marker of the vulnerable atherosclerotic plaque ', Clinical Biochemistry, vol. 44, no. 4, pp. 312-8 . https://doi.org/10.1016/j.clinbiochem.2010.12.010 |
| ISSN: | 0009-9120 |
| Popis: | Objective To investigate if pregnancy associated plasma protein-A (PAPP-A) was present in the vulnerable plaque, and if not, to find alternative hypothesis for the release of PAPP-A. Design and methods Vulnerable plaques and control tissues were examined by immunohistochemistry. Volunteers and patients with non-atherosclerotic disease were examined for release of PAPP-A during ischemia and medical treatment. Non-atherosclerotic tissue samples were examined after incubation with heparins. Results We were not able to detect PAPP-A in vulnerable plaques. Patients and volunteers experiencing ischemic events without atherosclerotic lesions only had elevated PAPP-A when treated with heparin. When tissue from normal artery wall was incubated with heparin, PAPP-A was eluted. This was not the case for non-arterial tissue samples. Conclusion Elevation of PAPP-A in patients with acute coronary syndromes seems to be caused by heparin induced release of PAPP-A from the arterial wall and not due to excretion from vulnerable plaques. |
| Databáze: | OpenAIRE |
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