Endothelial Adhesion Molecules Are Associated with Inflammation in Subjects with HIV Disease
| Autor: | Mark M. Melendez, Margaret A. McNurlan, Marie C. Gelato, Dennis C. Mynarcik, Shilpi Khan |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Microbiology (medical) Statistics as Topic Intercellular Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 HIV Infections Inflammation Disease Insulin resistance Immunopathology Humans Receptors Tumor Necrosis Factor Type II Medicine Cell adhesion business.industry Cell adhesion molecule medicine.disease Lipids Infectious Diseases Cardiovascular Diseases Immunology Regression Analysis Female Insulin Resistance medicine.symptom business Viral load Biomarkers |
| Zdroj: | Clinical Infectious Diseases. 46:775-780 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/527563 |
| Popis: | Background The presence of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) is associated with elevated risk of cardiovascular disease. Subjects with human immunodeficiency virus (HIV) disease have multiple risk factors for cardiovascular disease, including elevated serum lipid levels, insulin resistance, and elevated levels of ICAM-1 and VCAM-1. This study assessed the variables associated with elevated adhesion molecule levels in this patient population. Methods Serum levels of ICAM-1 and VCAM-1 were assessed in 31 subjects without HIV disease and 52 subjects with HIV disease. Pearson correlation indicated a significant relationship between ICAM concentration and other variables, including CD4+ cell count, HIV viral burden, insulin sensitivity, and serum lipid level. Multiple regression modeling was used to determine the strengths of association among the variables. Results Subjects with HIV disease had elevated levels of ICAM-1 and VCAM-1. Pearson correlation analysis revealed significant associations between ICAM-1 and VCAM-1 level and insulin sensitivity, plasma lipid level, and presence of type 2 soluble receptor for tumor necrosis factor-alpha (sTNFR2). With multiple regression modeling to control for interdependence, only sTNFR2, a marker of inflammation, was an independent predictor of ICAM-1 and VCAM-1 levels. Conclusions The study suggests that many of the variables associated with ICAM-1 and VCAM-1 levels can be related to their impact on inflammation. |
| Databáze: | OpenAIRE |
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