Ent-abietane diterpenoid lactone glycosides and a phenolic glycoside from Phlogacanthus pulcherrimus T. Anderson with cytotoxic and cancer chemopreventive activities

Autor:	Surasak Kheawchaum, Chulabhorn Mahidol, Sanit Thongnest, Jutatip Boonsombat, Paratchata Batsomboon, Somkid Sitthimonchai, Somsak Ruchirawat, Hunsa Prawat
Rok vydání:	2022
Předmět:	Lactones Molecular Structure Acanthaceae Neoplasms Abietanes Humans Plant Science General Medicine Glycosides Horticulture Molecular Biology Biochemistry HeLa Cells
Zdroj:	Phytochemistry. 201
ISSN:	1873-3700
Popis:	Nine undescribed ent-abietane diterpenoid lactone glycosides, pulcherrimosides A-I, and a phenolic glycoside, phlogoside A, together with ten known compounds were isolated from the aerial parts of Phlogacanthus pulcherrimus T. Anderson. Their structures were established through spectral methods, especially 2D NMR and HRESIMS analyses, and by acid hydrolysis. The absolute configurations of pulcherrimosides A-I were determined through the interpretation of electronic circular dichroism (ECD) data. Some of the isolates were evaluated for their in vitro cytotoxic and cancer chemopreventive properties. Helioscopinolide A and 17-hydroxyhelioscopinolide A showed good cytotoxic activity against HeLa cells with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2805579c5f8b05ff13010d963a34ef22 https://pubmed.ncbi.nlm.nih.gov/35662549 Zobrazit plný text záznamu Full Text from ScienceDirect