Effect of D ala2 metenkephalinamide on feline jejunal and ileal water and electrolyte transport
| Autor: | Cathy Dumas, AR Chikhlssa, Gerard Jourdan, A. Desvigne, G. Charpin, C. Caillet, A. Gharzouli, Danielle Pansu, Monique Descroix-Vagne |
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| Rok vydání: | 1990 |
| Předmět: |
Embryology
medicine.medical_specialty Sodium Bicarbonate Enkephalin Methionine Medicine (miscellaneous) chemistry.chemical_element Ileum Biology Calcium Jejunum 03 medical and health sciences chemistry.chemical_compound Electrolytes 0302 clinical medicine Body Water Chlorides Internal medicine medicine Animals Ion transporter 030304 developmental biology Calcium metabolism 0303 health sciences Biological Transport 3. Good health Bicarbonates medicine.anatomical_structure Endocrinology Reproductive Medicine chemistry Intestinal Absorption Cats Potassium 030211 gastroenterology & hepatology Animal Science and Zoology Mannitol Developmental Biology Food Science medicine.drug |
| Zdroj: | Reproduction, nutrition, development. 30(6) |
| ISSN: | 0926-5287 |
| Popis: | The aim of this investigation was to compare the effect of an opioid, D ala2 metenkephalinamide (DAMA), on net jejunal and ileal water and electrolyte fluxes using the gut perfusion technique in the anesthetized cat. Intestinal transport was measured during intravenous infusion of serial doses of 2, 6, and 18 micrograms.kg-1.h-1 of DAMA in 6 cats. Each cat was its own control during an intravenous infusion of 150 mmol/l NaCl preceding the first dose of peptide and following the last dose of DAMA. Both jejunal and ileal segments were isolated by inflated balloons and were studied at the same time. Fifteen ml of an iso-osmolar test solution with hypo-osmolar ion contents and complementary mannitol were administered in the upstream tube and collected 1 h later in the downstream tube. In the jejunum, water secretion was dose-dependently reversed to an absorption from a control value of +0.5 +/- 0.4 to -0.83 +/- 0.5 ml.h-1.10 cm-1; in the ileum, water absorption was increased from -0.5 +/- 0.3 to -1.5 +/- 0.2 ml.h-1.10 cm-1. The net absorption of all electrolytes, ie sodium, chloride, bicarbonate, potassium and calcium also increased during peptide administration. However, a qualitative difference in the ion transport was observed between the jejunum and the ileum. |
| Databáze: | OpenAIRE |
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