Effect of erythropoietin on cardiovascular prognosis parameters in hemodialysis patients
| Autor: | Helga Frank, Peter Huber, Roland E. Schmieder, Hans P. Schobel, Bernd Höffken, Karsten Heusser |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty sympathetic nerve activity Anemia medicine.medical_treatment Blood Pressure Baroreflex Left ventricular hypertrophy renal insufficiency Renal Dialysis Internal medicine medicine Humans Longitudinal Studies Prospective Studies Aged business.industry Middle Aged Prognosis medicine.disease anemia Recombinant Proteins Blood pressure medicine.anatomical_structure Endocrinology Echocardiography Regional Blood Flow Vascular resistance Cardiology Kidney Failure Chronic Female Hypertrophy Left Ventricular erythropoietin Hemodialysis business Kidney disease |
| Zdroj: | Kidney International. 66(2):832-840 |
| ISSN: | 0085-2538 |
| DOI: | 10.1111/j.1523-1755.2004.00810.x |
| Popis: | Effect of erythropoietin on cardiovascular prognosis parameters in hemodialysis patients.BackgroundRenal anemia is an important determinant for left ventricular hypertrophy in dialysis patients and an independent prognosis parameter for the cardiovascular survival in dialysis patients. In addition, an autonomic dysfunction is associated with the uremic state and influences the cardiovascular risk in patients with end-stage renal disease (ESRD).MethodsWe investigated in this prospective longitudinal study the effect of hemoglobin normalization by a chronic treatment with recombinant human erythropoietin (rhEPO) on cardiovascular prognosis parameters in 23 patients on chronic hemodialysis with renal anemia (hemoglobin concentration≤10.5 g/dL) and echocardiographically proven left ventricular hypertrophy. We studied muscle sympathetic nerve activity measured by microneurography; cardiopulmonary baroreflex activity by lower-body negative pressure (LBNP-) testing; left ventricular structure and mass index (LVMI) by echocardiography; blood pressure by 24-hour readings; peripheral blood flow and vascular resistance by plethysmography before (U1) and after 7 months of chronic rhEPO treatment (U2).ResultsIn the anemic state, mean (± SD) muscle sympathetic nerve activity in ESRD was elevated (U1 rest, 34 ± 13 bursts per minute) and cardiopulmonary baroreflex response during LBNP markedly lacking (U1 –15 mm Hg, 34 ± 13 bursts per minute) reflecting a severely impaired autonomic function. Normalization of the hemoglobin concentration by chronic rhEPO treatment (U1, 10.5 ± 0.9 g/dL versus U2, 13.4 ± 3.1 g/dL, P |
| Databáze: | OpenAIRE |
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