Antinociceptive effects of ceftriaxone in formalin‐induced nociception
| Autor: | Crystell Guadalupe Guzmán-Priego, Jorge E. Torres-López, Valeria Reyes-Pérez, Erick J. Rodríguez‐Palma, Guadalupe del Carmen Baeza-Flores |
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| Rok vydání: | 2020 |
| Předmět: |
Nociception
Formalin Test Analgesic Pain Pharmacology Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Formaldehyde Drug Discovery medicine Animals Rats Wistar Analgesics Chemistry Ceftriaxone Glutamate receptor Inflammatory pain Anti-Bacterial Agents 030220 oncology & carcinogenesis Female Injections Intraperitoneal 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Drug Development Research. 81:728-735 |
| ISSN: | 1098-2299 0272-4391 |
| DOI: | 10.1002/ddr.21680 |
| Popis: | Ceftriaxone (CFX) is a β-lactam antibiotic with analgesic properties. However, its role in the formalin-induced nociception remains unknown. The purpose of this study was to investigate the antinociceptive effect of CFX in the 1% formalin test in rats. Formalin induced a typical nociceptive response (flinching behavior) of two phases. Local peripheral pretreatment (20 min) with CFX (400-800 μg/paw) slightly attenuated the flinching behavior in phase 2, but not phase 1. Acute intraperitoneal pretreatment (20 min) also reduced phase 2 of the formalin test. In both cases, CFX induced a dose-dependent antinociception. We also tested the effect of CFX 1 day after its administration and in two schedules of repeated administration. One-day pretreatment with CFX (50-400 mg/kg, ip) induced a dose-dependent antinociceptive effect in formalin-treated rats. Repeated administration (daily during 3 or 7 days) with CFX (50-400 mg/kg, ip) diminished formalin-induced nociception. Results suggest that local or systemic as well as single or repeated administration of CFX reduces formalin-induced nociception. |
| Databáze: | OpenAIRE |
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