Insulin binding to erythrocytes in hyperinsulinemic patients with precirrhotic hemochromatosis and cirrhosis
| Autor: | Wolfgang Stremmel, A. S. Petrides, H. Reinauer, W. Paßlack, Georg Strohmeyer |
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| Rok vydání: | 1987 |
| Předmět: |
Blood Glucose
Liver Cirrhosis medicine.medical_specialty Erythrocytes Cirrhosis medicine.medical_treatment Liver disease Insulin resistance Hyperinsulinism Internal medicine Drug Discovery Hyperinsulinemia Humans Insulin Medicine Genetics (clinical) Hemochromatosis biology business.industry General Medicine medicine.disease Receptor Insulin Insulin receptor Endocrinology Insulin receptor binding biology.protein Molecular Medicine Insulin Resistance business |
| Zdroj: | Klinische Wochenschrift. 65:873-878 |
| ISSN: | 1432-1440 0023-2173 |
| DOI: | 10.1007/bf01737009 |
| Popis: | This study investigated insulin receptor binding (number and affinity) to erythrocytes in patients with precirrhotic hemochromatosis, patients with cirrhosis, and healthy subjects. To evaluate plasma glucose and insulin levels, an oral glucose tolerance test (OGTT) was performed in all subjects. In the fasting state, all patients exhibited normal glucose levels. Precirrhotic patients showed slight impairment of glucose tolerance while cirrhotic patients were strikingly glucose intolerant. In both patient groups, fasting plasma insulin levels were increased. Following the glucose load, plasma insulin levels were significantly enhanced in precirrhotic patients at 90 and 120 min and increased at all times in cirrhotic patients. In the postabsorptive state (in the presence of hyperinsulinemia) insulin binding and the number and affinity of insulin receptors of erythrocytes were not different in precirrhotic or cirrhotic patients when compared to controls. We conclude that studies of insulin binding on erythrocytes do not contribute to the evaluation of the pathogenesis of insulin resistance in liver disease. |
| Databáze: | OpenAIRE |
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