Native Valve Endocarditis Caused by Corynebacterium striatum with Heterogeneous High-Level Daptomycin Resistance: Collateral Damage from Daptomycin Therapy?
| Autor: | Audrey Wanger, Heidi B. Kaplan, Siraya Jaijakul, Cesar A. Arias, Barbara E. Murray, Truc T. Tran, Diana Panesso, Cole T. Lewis, Lorena Diaz |
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| Přispěvatelé: | Panesso, Diana [0000-0002-4049-9702] |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Methicillin-Resistant Staphylococcus aureus Cefotaxima Skin flora Bacteremia Drug resistance Biology Clinical Therapeutics Corynebacterium medicine.disease_cause Microbiology Daptomycin Drug Resistance Bacterial medicine polycyclic compounds Endocarditis Humans Pharmacology (medical) Pharmacology Native Valve Endocarditis Osteomyelitis Endocarditis Bacterial biochemical phenomena metabolism and nutrition Middle Aged medicine.disease biology.organism_classification bacterial infections and mycoses Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents carbohydrates (lipids) Infectious Diseases Antibacterianos lipids (amino acids peptides and proteins) Staphylococcus aureus resistente a la meticilina medicine.drug |
| Zdroj: | Repositorio U. El Bosque Universidad El Bosque instacron:Universidad El Bosque |
| Popis: | We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of ≤0.094 μg/ml) and high-level resistance to daptomycin (MIC of ≥256 μg/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin. |
| Databáze: | OpenAIRE |
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