The DAMA25 Study: Feasibility of a Lifestyle Intervention Programme for Cancer Risk Reduction in Young Italian Women with Breast Cancer Family History
| Autor: | Calogero Saieva, Ilaria Ermini, Domenico Palli, Daniela Occhini, Benedetta Bendinelli, Lisa Sequi, Melania Assedi, Maria Castaldo, Giovanna Masala, Ines Zanna, Luigi Facchini, Saverio Caini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Counseling
Waist Activities of daily living Health Toxicology and Mutagenesis Physical activity physical activity Breast Neoplasms single-arm intervention Article familial breast cancer risk young women diet Weight loss Risk Factors Intervention (counseling) medicine Humans Family history Life Style business.industry Public Health Environmental and Occupational Health Cancer Anthropometry medicine.disease Feasibility Studies Medicine Female medicine.symptom business Risk Reduction Behavior Demography |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 12287, p 12287 (2021) International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health; Volume 18; Issue 23; Pages: 12287 |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Background: Diet and physical activity (PA) can modulate sporadic and possibly familial breast cancer (BC) risk. The DAMA25 study is a single-arm 12-month intervention aimed to modify dietary and PA habits in healthy young Italian women with a positive BC family history, categorized as having intermediate or high genetic risk according to NICE (National Institute for Health and Cancer Excellence) guidelines. Methods: Participants, aged 25–49 years, were asked to adopt a diet mainly based on plant-based foods and to increase moderate daily activities combined with 1 h/week of more intense activity. Cooking lessons, collective walks, educational sessions, brochures, booklets and online materials were implemented. Dietary, PA habits and anthropometry were collected at baseline and at the end of the intervention. Changes on dietary, lifestyle habits and anthropometry were evaluated by GLM adjusted for weight reduction counselling aimed to participant with a BMI ≥ 25, age and baseline values of each variable. Results: Out of 237 eligible women 107 (45.2%) agreed to participate and among them 98 (91.6%) completed the intervention. The adherence rate of the intervention was 77.8%. We observed a reduction in red and processed meat (p < 0.0001) and cakes consumption (p < 0.0001). Consumption of whole grain bread (p < 0.001), leafy vegetables (p = 0.01) and olive oil (p = 0.04) increased. We observed an increase in moderate (p < 0.0001) and more intense (p < 0.0001) recreational activities, an average 1.4 kg weight loss (p = 0.005), a reduction of waist circumference (p < 0.001) and fat mass (p = 0.015). Conclusions: The DAMA25 study shows that it is feasible an intervention to improve in the short-term dietary and PA habits and anthropometry in women with high BC familial risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|