Visualizing the architectures and interactions of nuclear receptors
| Autor: | Sepideh Khorasanizadeh, Fraydoon Rastinejad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Proteomics medicine.medical_specialty Receptors Cytoplasmic and Nuclear Nanotechnology Computational biology Biology Crystallography X-Ray Invited Mini-Review 03 medical and health sciences chemistry.chemical_compound Endocrinology Internal medicine Coactivator medicine Animals Humans DNA humanities Chromatin DNA metabolism 030104 developmental biology chemistry Nuclear receptor human activities Transcription Factors |
| DOI: | 10.1210/en.2016-1559 |
| Popis: | Nuclear receptors (NRs) are master regulators of broad genetic programs in metazoans. These programs are regulated in part by the small-molecule ligands that bind NRs and modulate their interactions with transcriptional coregulatory factors. X-ray crystallography is now delivering more complete pictures of how the multidomain architectures of NR homo- and heterodimers are physically arranged on their DNA elements and how ligands and coactivator peptides act through these complexes. Complementary studies are also pointing to a variety of novel mechanisms by which NRs access their DNA-response elements within chromatin. Here, we review the new structural advances together with proteomic discoveries that shape our understanding of how NRs form a variety of functional interactions with collaborating factors in chromatin. |
| Databáze: | OpenAIRE |
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