Myasthenia Gravis Revealing Hodgkin's Lymphoma
| Autor: | Yousfi, Jaouad, Bensalek, Fatimazahra, Zahlane, Mouna, Benjilali, Laila, Essaadouni, Lamiaa |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Journal of Case Reports in Internal Medicine (2021) Eur J Case Rep Intern Med |
| ISSN: | 2284-2594 |
| Popis: | INTRODUCTION: Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction. PATIENT AND METHODS: We report the case of a young patient with myasthenia gravis associated with Hodgkin’s lymphoma. RESULTS: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ≤0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin’s lymphoma. CONCLUSION: The association of lymphomas with myasthenia gravis has been rarely reported. LEARNING POINTS: Myasthenia gravis is an autoimmune disease of the neuromuscular junction and can be associated with malignant haemopathy. The coexistence of myasthenia and Hodgkin’s lymphoma is very rare. This association is a therapeutic challenge. |
| Databáze: | OpenAIRE |
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