Soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for differential diagnosis of mild cognitive impairment
| Autor: | Kotaro Hattori, Wataru Araki, Yuma Yokoi, Yuko Saito, Kazutomi Kanemaru, Masuhiro Sakata, Hisateru Tachimori, Shigeo Murayama, Yoshie Omachi, Harumasa Takano, Hidehiro Mizusawa, Masahiro Nagao, Takashi Komori, Tadashi Tsukamoto, Sumiko Yoshida, Utako Nagaoka |
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| Rok vydání: | 2021 |
| Předmět: |
Aging
medicine.medical_specialty Amyloid tau Proteins Neuropathology behavioral disciplines and activities Diagnosis Differential Amyloid beta-Protein Precursor Cerebrospinal fluid Alzheimer Disease Internal medicine mental disorders medicine Humans Cognitive Dysfunction Cognitive impairment Amyloid beta-Peptides business.industry Control subjects Peptide Fragments Endocrinology Potential biomarkers Biomarker (medicine) Geriatrics and Gerontology Differential diagnosis business human activities Biomarkers |
| Zdroj: | Aging Clinical and Experimental Research. 34:341-347 |
| ISSN: | 1720-8319 |
| Popis: | Concentrations of soluble amyloid precursor proteins-α (sAPPα) and -β (sAPPβ) in cerebrospinal fluid (CSF) may reflect the neuropathology of Alzheimer’s disease (AD). We previously reported that the concentrations of both sAPPα and sAPPβ were significantly higher in patients with mild cognitive impairment (MCI) due to AD (MCI-AD) than in control subjects without cognitive impairment. The present study analyzed whether these sAPPs are useful in the differential diagnosis of MCI. A modified and sensitive method was used to analyze concentrations of sAPPα and sAPPβ in CSF of patients with MCI-AD (n = 30) and MCI due to other causes (MCI-others) (n = 24). Phosphorylated tau (p-tau) and amyloid β-protein 42 (Aβ42) were also analyzed using standard methods. CSF concentrations of sAPPα and sAPPβ were significantly higher in the MCI-AD than in the MCI-others group (p |
| Databáze: | OpenAIRE |
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