Has lung cancer in the elderly different characteristics at presentation?
Autor: | Anna Crispo, Cesare Gridelli, Pasquale Ruffolo, P. Maione, Tindaro Gatani, Gabriella Fabbrocini, Francesco Scognamiglio, Maurizio Montella, Vincenzo Boccia |
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Přispěvatelé: | Montella, M, Gridelli, C, Crispo, A, Scognamiglio, F, Ruffolo, P, Gitani, T, Boccia, V, Maione, P, Fabbrocini, Gabriella |
Rok vydání: | 2002 |
Předmět: |
Adult
Male Oncology Aging Cancer Research medicine.medical_specialty Lung Neoplasms Small-cell carcinoma Carcinoma Non-Small-Cell Lung Internal medicine Odds Ratio Humans Medicine Age of Onset Lung cancer Aged Performance status business.industry Respiratory disease Age Factors Cancer General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Surgery Logistic Models Female Age of onset business |
Zdroj: | Scopus-Elsevier |
ISSN: | 1791-2431 1021-335X |
Popis: | Lung cancer is the first cause of cancer death for males agedor =35 years, and the second for females aged between 35 and 70 years. Elderly patients seem to have the worst performance status (PS) and earlier stage of disease at diagnosis. We analyzed data concerning 1,035 patients with lung cancer referred to the National Cancer Institute of Naples. The variables considered in the analysis were: gender; type of cancer [small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC)]; ECOG (Eastern Cooperative Oncology Group) PS, the stage of disease at diagnosis, the histological type, age at diagnosis. In order to better assess the relevance of age at diagnosis in lung cancer patients we categorized the age into two groups (youngor =70; old70 years). The statistical analyses were performed using chi2 trend test with corresponding p-value and odds ratios (OR) for the examined variables, with a corresponding 95% confidence interval. These were derived using multiple logistic regression, fitted by the maximum likelihood method. For all the 1035 patients the risk between the age at diagnosis and the performance status was not statistically significant (OR=1.1, 95%CI 0.8-1.5). We repeated the same risk distinguishing the histological type and we analyzed the performance status for the SCLC (OR=1.0, 95%CI 0.4-2.5) and the stage at diagnosis (OR=1.0, 95%CI 0.4-3.0), without any significant difference. Our study showed that elderly patients with lung cancer do not seem to have different characteristics at presentation, particularly related to stage of disease, PS and histology, as compared to their younger counterpart. Other characteristics such as type and number of co-morbidities and organ function differ in the two groups of populations. |
Databáze: | OpenAIRE |
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