The impact of environmental enrichment on the murine inflammatory immune response
| Autor: | Mauro Perretti, Beatrice R. Gittens, Fulvio D'Acquisto, Masahiro Ono, Thomas Gobbetti, Samuel Brod |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Neutrophils Phagocytosis Inflammation Biology Environment Peritonitis Sepsis 03 medical and health sciences Peritoneal cavity Mice Immune system medicine Animals Neutrophil to lymphocyte ratio Cecum Ligation Environmental enrichment Macrophages Zymosan General Medicine medicine.disease Microarray Analysis Disease Models Animal 030104 developmental biology medicine.anatomical_structure Immunology medicine.symptom Ex vivo Research Article |
| Zdroj: | JCI Insight |
| ISSN: | 2379-3708 |
| Popis: | Living in a mentally and physically stimulating environment has been suggested to have a beneficial effect on the immune response. This study investigates these effects, utilizing a 2-week program of environmental enrichment (EE) and 2 models of acute inflammation: zymosan-induced peritonitis (ZIP) and the cecal ligation and puncture (CLP) model of sepsis. Our results revealed that following exposure to EE, mice possessed a significantly higher circulating neutrophil to lymphocyte ratio compared with control animals. When subject to ZIP, EE animals exhibit enhanced neutrophil and macrophage influx into their peritoneal cavity. Corresponding results were found in CLP, where we observed an improved capacity for enriched animals to clear systemic microbial infection. Ex vivo investigation of leukocyte activity also revealed that macrophages from EE mice presented an enhanced phagocytic capacity. Supporting these findings, microarray analysis of EE animals revealed the increased expression of immunomodulatory genes associated with a heightened and immunoprotective status. Taken together, these results provide potentially novel mechanisms by which EE influences the development and dynamics of the immune response. A housing period as little as 2 weeks in an enriched environment with an increase in spatial and sensorial stimuli improved the ability of mice to clear infections. |
| Databáze: | OpenAIRE |
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