Dopamine denervation in the functional territories of the striatum: a new MR and atlas-based 123I-FP-CIT SPECT quantification method
Autor: | Aurélie Kas, Sara Fernandez-Vidal, David Grabli, M-O Habert, Stéphane Lehéricy, Graziella Mangone, Nicolas Villain, J Aubert, O Jaubert, G. Bera, Romain Valabregue, J-C Corvol, Marie Vidailhet |
---|---|
Přispěvatelé: | Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), VILLAIN, Nicolas |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Parkinson's disease
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging striatum Partial volume idiopathic rapid eye movement sleep behavioral disorder Striatum Nucleus accumbens Dopamine Basal ganglia Medicine [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Biological Psychiatry Denervation [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology business.industry Dopaminergic medicine.disease Psychiatry and Mental health [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging Neurology nervous system 123 I-FP-CIT SPECT [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neurology (clinical) business Neuroscience [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology medicine.drug |
Zdroj: | Journal of Neural Transmission Journal of Neural Transmission, 2021, 128 (12), pp.1841-1852. ⟨10.1007/s00702-021-02434-9⟩ |
ISSN: | 0300-9564 1435-1463 |
Popis: | International audience; Current quantification methods of 123I-FP-CIT SPECT rely on anatomical parcellation of the striatum. We propose here to implement a new method based on MRI segmentation and functional atlas of the basal ganglia (MR-ATLAS) that could provide a reliable quantification within the sensorimotor, associative, and limbic territories of the striatum. Patients with Parkinson’s disease (PD), idiopathic rapid eye movement sleep behavioral disorder (iRBD), and healthy controls underwent 123I-FP-CIT SPECT, MRI, motor, and cognitive assessments. SPECT data were corrected for partial volume effects and registered to a functional atlas of the striatum to allow quantification in every functional region of the striatum (nucleus accumbens, limbic, associative, and sensorimotor parts of the striatum). The MR-ATLAS quantification method is proved to be reliable in every territory of the striatum. In addition, good correlations were found between cognitive dysexecutive tests and the binding within the functional (limbic) territories of the striatum using the MR-ATLAS method, slightly better than correlations found using the anatomical quantification method. This new MR-ATLAS method provides a robust and useful tool for studying the dopaminergic system in PD, particularly with respect to cognitive functions. It may also be relevant to further unravel the relationship between dopaminergic denervation and cognitive or behavioral symptoms. |
Databáze: | OpenAIRE |
Externí odkaz: |