Determination of urinary enzymes as a marker of early renal damage in diabetic patients
| Autor: | Solmaz Asgharzadeh-Haghighi, Rohollah Hosseini, Mahmoud Ghazi-Khansari, Ali Mohammadi-Karakani |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Blood Glucose Male medicine.medical_specialty Urinary system Clinical Biochemistry Urology Renal function urologic and male genital diseases Sensitivity and Specificity Diabetic nephropathy Excretion chemistry.chemical_compound Lactate dehydrogenase Diabetes mellitus Internal medicine Acetylglucosaminidase Immunology and Allergy Medicine Albuminuria Humans Diabetic Nephropathies Renal Insufficiency Glycated Hemoglobin Creatinine L-Lactate Dehydrogenase business.industry urogenital system Biochemistry (medical) Public Health Environmental and Occupational Health Hematology Original Articles Middle Aged medicine.disease Alkaline Phosphatase Medical Laboratory Technology Endocrinology chemistry Microalbuminuria Female business Biomarkers |
| Popis: | Diagnosis of diabetic nephropathy in the early stages is very important since there are no clinical signs or symptoms. Urinary N‐acetyl‐β‐D‐glucosaminidase (NAG) excretion has been recommended as a tubular dysfunction marker that elevates before other markers, such as microalbuminuria and a decrease in creatinine clearance. In this study, we compared excretion of urinary enzymes with other markers that are used routinely in diabetic nephropathy assessment. Urinary NAG, lactate dehydrogenase (LDH), alkaline phosphatase (AP) activities, urea, creatinine, and albumin, with levels of serum glucose and creatinine and whole blood glycosylated hemoglobin (HbA1c) were measured in 32 diabetes mellitus patients and 25 healthy subjects (controls). Notably, urinary NAG, AP, LDH excretion, and microalbuminuria in the diabetic patients group were significantly increased compared to those in the control groups (P |
| Databáze: | OpenAIRE |
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