The effect of beta-adrenergic blockade in dilated cardiomyopathy — a questionnaire study in Japan
Autor: | Hisakazu Yasuda, Chuichi Kawai, Shunnosuke Handa, Atsuyoshi Takao, Tsutomu Watanabe, Junichiro Mihune, Shoji Yasui, Hironori Toshima, Akira Matsumori, Sachihiko Nobuoka, Shuzo Matsuo, Toshitami Sawayama, Takeshi Nakano, Sokichi Onodera, Akira Kitabatake, Tetsuo Okamura, Hiroshi Yoshimura, Yasunori Fukuchi, Makoto Tominaga, Hirohide Matsuo |
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Rok vydání: | 1991 |
Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty Adolescent Adrenergic beta-Antagonists Propranolol Japan Internal medicine Heart rate medicine Humans Child Aged Metoprolol Heart Failure Ejection fraction business.industry Hemodynamics Dilated cardiomyopathy Middle Aged medicine.disease Cardiac surgery Survival Rate Blood pressure Child Preschool Anesthesia Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug |
Zdroj: | Heart and Vessels. 6:6-10 |
ISSN: | 1615-2573 0910-8327 |
Popis: | The effect of beta-blockade in dilated cardiomyopathy was studied by a questionnaire survey. Thirty-three cases were monitored in whom metoprolol (22 patients, 35.9 +/- 20.4 mg, mean +/- SD), propranolol (four patients, 26.3 +/- 7.5 mg), or other beta-blockers (seven patients) were administered. Four patients died, but no direct relationship was found between administration of beta-blocker and death. The NYHA functional class improved significantly. The mean heart rate decreased from 96/min to 77/min (P less than 0.01). The mean cardiothoracic ratio decreased from 55.6% to 52.1% (P less than 0.01). The mean ejection fraction of the left ventricle measured by echocardiogram increased from 30.4% to 36.9% (P less than 0.01). Exercise tolerance in the treadmill test improved significantly. There was no change in blood pressure, nor were there arrhythmias seen on Holter electrocardiograms. In two patients, congestive heart failure deteriorated after administration of beta-blockers. It is concluded that beta-adrenergic blockade has a beneficial effect in most of the patients with dilated cardiomyopathy. |
Databáze: | OpenAIRE |
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