17β-estradiol locally increases phasic dopamine release in the dorsal striatum
| Autor: | Wayne G. Brake, Peter Shizgal, Marie-Pierre Cossette, Waqqas M. Shams |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Microdialysis Dopamine Stimulation Substantia nigra Striatum Tonic (physiology) 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Rats Long-Evans Estradiol Chemistry General Neuroscience Corpus Striatum Electric Stimulation Substantia Nigra Amphetamine 030104 developmental biology Endocrinology Ovariectomized rat Systemic administration Female 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Neuroscience Letters. 665:29-32 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2017.11.039 |
| Popis: | Studies using in vivo microdialysis have shown that 17β-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anesthetized (1.5 mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum. Rats were ovariectomized and implanted with a silastic tube containing 5% E2 in cholesterol, previously shown to mimic low physiological serum concentrations of ∼ 20–25 pg/mL. DA release was evoked every 1 min by delivering biphasic electrical stimulation in the substantia nigra. Local infusions of E2 (244.8 pg/μl) into the dorsal striatum increased the amplitude of the electrically evoked DA transients. Behaviorally significant stimuli and events trigger phasic release of DA. The present findings predict that E2 would boost such signaling in behaving subjects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect