The common marmoset as an indispensable animal model for immunotherapy development in multiple sclerosis
| Autor: | Bert A. 't Hart, Jordon Dunham, Yolanda S. Kap, S. Anwar Jagessar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Herpesvirus 4 Human Encephalomyelitis Autoimmune Experimental Multiple Sclerosis medicine.medical_treatment Spleen Disease THERAPY DISEASE 03 medical and health sciences Mice 0302 clinical medicine Immune system DEMYELINATION biology.animal Drug Discovery B-CELL DEPLETION medicine Animals Humans Gray Matter MATTER PATHOLOGY Pharmacology B-Lymphocytes LESIONS biology Genetic heterogeneity Multiple sclerosis Experimental autoimmune encephalomyelitis Marmoset Callithrix CALLITHRIX-JACCHUS Immunotherapy medicine.disease 030104 developmental biology medicine.anatomical_structure EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS EAE MODEL Immunology Lymph Nodes WHITE-MATTER 030217 neurology & neurosurgery |
| Zdroj: | Drug Discovery Today. 21(8):1200-1205 |
| ISSN: | 1359-6446 |
| DOI: | 10.1016/j.drudis.2016.03.014 |
| Popis: | New drugs often fail in the translation from the rodent experimental autoimmune encephalomyelitis (EAE) model to human multiple sclerosis (MS). Here, we present the marmoset EAE model as an indispensable model for translational research into MS. The genetic heterogeneity of this species and lifelong exposure to chronic latent infections and environmental pathogens create a human-like immune system. Unique to this model is the presence of the pathological hallmark of progressive MS, in particular cortical grey matter lesions. Another great possibility of this model is systemic and longitudinal immune profiling, whereas in humans and mice immune profiling is usually performed in a single compartment (i.e. blood or spleen, respectively). Overall, the marmoset model provides unique opportunities for systemic drug-effect profiling. |
| Databáze: | OpenAIRE |
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