Prevalence of anti-histone antibodies, their clinical significance and correlation with other autoantibodies in a cohort of Italian scleroderma patients

Autor: Marilina Tampoia, Gabriella Pucci, Giovanni Lapadula, Francesca Scaccia, Antonella Simpatico, Irene Fineschi, Mauro Galeazzi, Gabriella Morozzi, Alessandra Chialà, Francesca Bellisai
Rok vydání: 2011
Předmět:
Zdroj: Auto-Immunity Highlights
ISSN: 2038-3274
2038-0305
DOI: 10.1007/s13317-011-0015-y
Popis: Purpose The aim of our study was to determine the prevalence, clinical significance of antibodies to individual histone components and to evaluate their correlation with other autoantibody specificities in a cohort of Italian SSc patients. Some authors, demonstrated high prevalence of anti-histone antibodies in Italian SSc patients, associated with cardiac and renal involvement, suggesting a prognostic value of these autoantibodies; however, these data need to be confirmed. Methods Serum from 112 adult SSc patients, classified as diffuse (dc) and limited cutaneous (lc) SSc subsets were analyzed for autoantibodies by indirect immunofluorescence, fluoroenzyme immunoassay and enzyme immunoassay. Results AHA were found in 13 patients (11.6%), nine with lcSSc and four with dcSSc. Among them, five patients were anti-Scl70+ and four were anti-CENP B+. The presence of AHA was not associated with multi-organ involvement or with diffuse subset, as already described. Anti-Scl70 was detected in 43% of patients, anti-CENP B in 32% and anti-RNA polymerase III in 7.1%. We confirmed the association between anti-Scl70 antibodies and pulmonary fibrosis (OR 15.75, p
Databáze: OpenAIRE
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