Progesterone and breast
| Autor: | Claudia Lanari, Caroline A. Lamb, Victoria Teresa Fabris |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
PROGESTERONE RECEPTOR ISOFORMS Mammary gland Breast Neoplasms Endometrium BREAST Ciencias Biológicas 03 medical and health sciences 0302 clinical medicine Breast cancer Biología Celular Microbiología Pregnancy BREAST CANCER Progesterone receptor medicine Humans Breast skin and connective tissue diseases Progesterone Breast development Fetus PROGESTINS Zygote business.industry Obstetrics and Gynecology PROGESTERONE General Medicine medicine.disease Hormones 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Female Progestins Receptors Progesterone business CIENCIAS NATURALES Y EXACTAS Hormone |
| Zdroj: | Best Practice & Research Clinical Obstetrics & Gynaecology. 69:85-94 |
| ISSN: | 1521-6934 |
| DOI: | 10.1016/j.bpobgyn.2020.04.001 |
| Popis: | Progesterone (Pg) is a pregnancy-related hormone that prepares the endometrium for the implantation of the fertilized zygote and suppresses myometrial contractility for the maintenance of pregnancy. At high concentrations, it acts as a natural immunosuppressant avoiding the rejection of a half allogeneic foetus. It is the precursor of many other related steroid hormones, but what is its role in the human breast? In this chapter, we will discuss some aspects related to Pg and its role in breast development and in the neoplastic disease. Understanding the mechanisms related to Pginduced effects in the normal and neoplastic mammary gland will light the way to exploit this hormone signalling pathway therapeutically. We will introduce some aspects of the effects of progestins in normal breast development, breast cancer risk and in neoplastic growth, and we will describe ongoing clinical trials in breast cancer using progestins or antiprogestins. Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect