Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats
| Autor: | Joerg Rossbacher, Pascale Perret, Katsutaro Morino, Esben S. Buhl, Dongyan Zhang, Varman T. Samuel, Allan Flyvbjerg, Susanne Neschen, Jung H. Kim, Kitt Falk Petersen, Gary W. Cline, Shin Yonemitsu |
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| Přispěvatelé: | Department of Pharmacology, Medical Research Laboratory, Department of Internal Medicine, Yale University School of Medicine, Radiopharmaceutiques biocliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Pathology, Yale School of Medicine [New Haven, Connecticut] (YSM), Perret, Pascale |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Physiology
MESH: Receptors Glucocorticoid Endocrinology Diabetes and Metabolism medicine.medical_treatment MESH: Random Allocation MESH: Insulin-Like Growth Factor I Pituitary-Adrenal System Type 2 diabetes MESH: Rats Sprague-Dawley MESH: Animals Newborn Rats Sprague-Dawley Random Allocation chemistry.chemical_compound Hypothalamic-Pituitary-Adrenal Axis 0302 clinical medicine MESH: Pregnancy MESH: Cholesterol Pregnancy Corticosterone MESH: Reverse Transcriptase Polymerase Chain Reaction Insulin MESH: Animals Insulin-Like Growth Factor I [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism 0303 health sciences Reverse Transcriptase Polymerase Chain Reaction MESH: Insulin-Like Growth Factor Binding Protein 1 Fasting [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism MESH: Restraint Physical MESH: Glucose MESH: Insulin Resistance Cholesterol medicine.anatomical_structure Liver MESH: Pituitary-Adrenal System Female Hypothalamic–pituitary–adrenal axis Restraint Physical MESH: Triglycerides Hypothalamo-Hypophyseal System medicine.medical_specialty MESH: Rats MESH: Fasting 030209 endocrinology & metabolism Adrenocorticotropic hormone MESH: Insulin [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine Biology MESH: Hypothalamo-Hypophyseal System Article [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine 03 medical and health sciences Receptors Glucocorticoid Insulin resistance Adrenocorticotropic Hormone Downregulation and upregulation Physiology (medical) Internal medicine medicine Animals MESH: Adrenocorticotropic Hormone Triglycerides 030304 developmental biology Low Birth Weight MESH: Phosphoenolpyruvate Carboxykinase (ATP) medicine.disease Rats Insulin-Like Growth Factor Binding Protein 1 Glucose Endocrinology Hepatic Insulin Resistance Animals Newborn chemistry Prenatal stress Insulin Resistance MESH: Corticosterone MESH: Female Phosphoenolpyruvate Carboxykinase (ATP) MESH: Liver |
| Zdroj: | AJP-Endocrinology and Metabolism AJP-Endocrinology and Metabolism, American Physiological Society, 2007, 293 (5), pp.E1451-8. ⟨10.1152/ajpendo.00356.2007⟩ Buhl, E S, Neschen, S, Yonemitsu, S, Rossbacher, J, Zhang, D, Morino, K, Flyvbjerg, A, Perret, P, Samuel, V, Kim, J, Cline, G W & Petersen, K F 2007, ' Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats ', Am. J. Physiol. Endocrinol. Metab., vol. 293, pp. E1451-8 . |
| ISSN: | 0193-1849 1522-1555 |
| DOI: | 10.1152/ajpendo.00356.2007⟩ |
| Popis: | International audience; Individuals born with a low birth weight (LBW) have an increased prevalence of type 2 diabetes, but the mechanisms responsible for this association are unknown. Given the important role of insulin resistance in the pathogenesis of type 2 diabetes, we examined insulin sensitivity in a rat model of LBW due to intrauterine fetal stress. During the last 7 days of gestation, rat dams were treated with dexamethasone and insulin sensitivity was assessed in the LBW offspring by a hyperinsulinemic euglycemic clamp. The LBW group had liver-specific insulin resistance associated with increased levels of PEPCK expression. These changes were associated with pituitary hyperplasia of the ACTH-secreting cells, increased morning plasma ACTH concentrations, elevated corticosterone secretion during restraint stress, and an approximately 70% increase in 24-h urine corticosterone excretion. These data support the hypothesis that prenatal stress can result in chronic hyperactivity of the hypothalamic-pituitary-adrenal axis, resulting in increased plasma corticosterone concentrations, upregulation of hepatic gluconeogenesis, and hepatic insulin resistance. |
| Databáze: | OpenAIRE |
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