Is amoxicillin-cotrimoxazole the most appropriate antibiotic regimen for listeria meningoencephalitis? Review of 22 cases and the literature
| Autor: | P. Maurer, L. Dossou-Gbete, A. Lozniewski, O. Kuntzburger, Ph. Meyer, M. Merle-Melet, Michel Weber, A. Gérard |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty medicine.disease_cause Group A Gastroenterology law.invention Listeria monocytogenes Meningoencephalitis law Internal medicine Ampicillin Trimethoprim Sulfamethoxazole Drug Combination medicine Humans Listeriosis Child Aged business.industry Amoxicillin Middle Aged medicine.disease Intensive care unit Trimethoprim Surgery Regimen Infectious Diseases Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Journal of Infection. 33:79-85 |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/s0163-4453(96)92929-1 |
| Popis: | From June 1983 to January 1994, 22 adult patients with severe Listeria monocytogenes meningoencephalitis were observed in our Intensive Care Unit. Listeria monocytogenes was obtained in culture in cerebrospinal fluid or blood for every patient. Seven patients were treated with the combination ampicillin-aminoglycoside (group A) and 15 patients with the combination ampicillin (or amoxicillin)-cotrimoxazole (group A + C). Risk factors and gravity scores were similar in both groups. Failure of the 'gold standard' regimen (group A) was significantly higher (57%) compared to group A + C (6.7%) (P < 0.05). Mortality related to L. monocytogenes was 23.5% in group A compared to 6.7% in group A + C. Morbidity was reduced in group A + C (13.3%) compared to group A (60%) (P = 0.15). This unique study seems to demonstrate that amoxicillin-cotrimoxazole should be the most appropriate therapeutic regimen for Listeria meningoencephalitis. |
| Databáze: | OpenAIRE |
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