Obesity and the prevention of thyroid cancer: Impact of body mass index and weight change on developing thyroid cancer - Pooled results of 24 million cohorts
| Autor: | Mohamed Saied Abdelgawad, Carlos A. Galvani, Abdallah S. Attia, Eman A. Toraih, Gregory W. Randolph, Mohamed Aboueisha, Anna LaRussa, Emad Kandil, Adin S. C. Reisner, Mohamed Hosny Hussein, Mahmoud Omar, Mohanad R. Youssef |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Weight Gain Risk Assessment Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Sex Factors Thinness Risk Factors Internal medicine medicine Confidence Intervals Humans Obesity Thyroid Neoplasms Risk factor 030223 otorhinolaryngology Thyroid cancer Cancer prevention business.industry Weight change Body Weight Publication bias Overweight medicine.disease Oncology 030220 oncology & carcinogenesis Relative risk Female Oral Surgery Underweight medicine.symptom business Body mass index Publication Bias |
| Zdroj: | Oral oncology. 112 |
| ISSN: | 1879-0593 |
| Popis: | Body weight may be a modifiable risk factor predisposing to different cancers. To establish a potential impact of weight change on thyroid cancer risk, we conducted a meta-analysis to evaluate the effect of body mass index (BMI) and weight change over time as a risk of developing thyroid cancer (TC).A systematic search was performed up to February 25, 2020. Pooled relative risk (RR) were estimated using fixed and random models. Heterogeneity between articles was examined using Q-test and IA total of 31 studies including 24,489,477 cohorts were eligible. Pooled analysis revealed that normal and underweight cohorts were associated with a decreased risk of TC (RR = 0.68, 95%CI = 0.65-0.71, p 0.001) and (RR = 0.92, 95%CI = 0.91-0.93, p 0.001), respectively. In contrast, overweight and obese cohorts were more likely to develop TC (RR = 1.26, 95%CI = 1.24-1.28, p 0.001 and RR = 1.50, 95%CI = 1.45-1.55, p 0.001, respectively). Obesity was associated with higher risk of developing TC among women (RR = 1.29, 95%CI = 1.14-1.46, p 0.001), but not men (RR = 1.25, 95%CI = 0.97-1.62, p = 0.08). Furthermore, weight gain increased the risk of developing TC (RR = 1.18, 95%CI = 1.14-1.22, p 0.001), while weight loss decreased the risk (RR = 0.89, 95%CI = 0.85-0.93, p 0.001). Results showed similar trends of weight change effect in both males and females.Obesity is associated with higher risk of developing TC in women. However, maintaining a healthy weight is associated with reduced risk of TC in both women and men. Shifting our practice to include weight control strategies will help lead to cancer prevention. |
| Databáze: | OpenAIRE |
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