Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m)
| Autor: | Owen Thomas, Stephen D. Myers, Kimberly M. Ashdown, Kelsey E. Joyce, Charles Newman, Carla A. Rue, William L. Malein, Samuel J. E. Lucas, Arthur R. Bradwell, Patrick Cadigan, Alex D. Wright, John Delamere, Brian G. Johnson, Fiona A. Myers, Mark E. Edsell, Christopher H.E. Imray |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Supine position pulmonary Physical Therapy Sports Therapy and Rehabilitation Angiotensin II receptor antagonist Placebo Q1 RC1200 R5-920 Internal medicine Heart rate medicine Orthopedics and Sports Medicine Original Research exercise business.industry cardiovascular Effects of high altitude on humans medicine.disease Pulmonary hypertension QP Losartan Blood pressure Cardiology business altitude medicine.drug RC |
| Zdroj: | Lucas, S J E, Malein, W L, Thomas, O D, Ashdown, K M, Rue, C A, Joyce, K E, Newman, C, Cadigan, P, Johnson, B, Myers, S D, Myers, F A, Wright, A D, Delamere, J, Imray, C H E, Bradwell, A R & Edsell, M 2021, ' Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m) ', BMJ Open Sport and Exercise Medicine, vol. 7, no. 1, e000982 . https://doi.org/10.1136/bmjsem-2020-000982 BMJ Open Sport & Exercise Medicine, Vol 7, Iss 1 (2021) BMJ Open Sport — Exercise Medicine |
| ISSN: | 2055-7647 |
| DOI: | 10.1136/bmjsem-2020-000982 |
| Popis: | ObjectiveAltitude-related and exercise-related elevations in blood pressure (BP) increase the likelihood of developing pulmonary hypertension and high-altitude illness during high-altitude sojourn. This study examined the antihypertensive effect and potential exercise benefit of the angiotensin II receptor antagonist losartan when taken at altitude.MethodsTwenty participants, paired for age and ACE genotype status, completed a double-blinded, randomised study, where participants took either losartan (100 mg/day) or placebo for 21 days prior to arrival at 5035 m (Whymper Hut, Mt Chimborazo, Ecuador). Participants completed a maximal exercise test on a supine cycle ergometer at sea level (4 weeks prior) and within 48 hours of arrival to 5035 m (10-day ascent). Power output, beat-to-beat BP, oxygen saturation (SpO2) and heart rate (HR) were recorded during exercise, with resting BP collected from daily medicals during ascent. Before and immediately following exercise at 5035 m, extravascular lung water prevalence was assessed with ultrasound (quantified via B-line count).ResultsAt altitude, peak power was reduced relative to sea level (p2 (70±6 vs 70±5%, p=0.96) and HR (146±21 vs 149±24 bpm, p=0.78) were similar between groups at peak power, as was the increase in systolic BP from rest to peak power (up 80±37 vs 69±33 mm Hg, p=0.56). Exercise increased B-line count (pConclusionLosartan had no observable effect on resting or exercising BP, exercise-induced symptomology of pulmonary hypertension or performance at 5035 m. |
| Databáze: | OpenAIRE |
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