Cholesterol regulatory effects and antioxidant activities of protein hydrolysates from zebra blenny (Salaria basilisca) in cholesterol-fed rats
| Autor: | Fatma Makni-Ayedi, Moncef Nasri, Ahmed Boualga, Riadh Ben Salah, Tahia Boudaouara, Abdelfattah El Feki, Ibtissem Ben Amara, Naourez Ktari, Mouna Turki, Aïda Ben Hadj, Olfa Belguith-Hadriche |
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| Rok vydání: | 2015 |
| Předmět: |
Fish Proteins
Male medicine.medical_specialty Antioxidant Protein Hydrolysates medicine.medical_treatment Hypercholesterolemia Biology Antioxidants Cholesterol Dietary Superoxide dismutase chemistry.chemical_compound Internal medicine Hyperlipidemia medicine TBARS Animals Humans Rats Wistar Triglycerides chemistry.chemical_classification Superoxide Dismutase Cholesterol Glutathione peroxidase Cholesterol HDL Fishes Cholesterol LDL General Medicine Catalase medicine.disease Oxidative Stress Endocrinology Liver chemistry biology.protein Alkaline phosphatase Uric acid Food Science |
| Zdroj: | Food & Function. 6:2273-2282 |
| ISSN: | 2042-650X 2042-6496 |
| DOI: | 10.1039/c5fo00492f |
| Popis: | This study aims to explore the hypocholesterolemic effects and antioxidative activities of zebra blenny protein hydrolysates (ZBPHs) in rats fed with a hypercholesterolemic diet. The rats were fed during eight weeks a standard laboratory diet (normal rats), a high-cholesterol diet (HCD) (1%) or a HCD and orally treated with ZBPHs or undigested zebra blenny proteins (UZBPs) (400 mg per kg per day). Results showed that a hypercholesterolemic diet induced the increase of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C). Treatment with ZBPHs increased the level of high-density lipoprotein cholesterol (HDL-C) and decreased significantly the levels of TC, TG, and LDL-C. In addition, ZBPH treatment showed significant normalization of thiobarbituric acid-reactive substance (TBARS) levels as well as catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in renal and hepatic tissues. Furthermore, ZBPHs may also exert significant protective effects on liver and kidney functions, evidenced by a marked decrease in the level of serum urea, uric acid, creatinine, alkaline phosphatase (ALP), and alanine aminotransferase (ALAT). Histological studies confirmed that ZBPHs effectively protected the livers and kidneys against hypercholesterolemia-mediated oxidative damage. Therefore, the study strengthens the hypothesis that ZBPHs can be used as novel antioxidants and hypocholesterolemic compounds against hyperlipidemia induced atherosclerosis. |
| Databáze: | OpenAIRE |
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