Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action

Autor: M. Gallo, Loredana Gandini, Andrea Lenzi, Francesco Lombardo, Sebastio Perrini, Nicola delli Muti, Giacomo Tirabassi, Donatella Paoli, Angelo Cignarelli, Giorgio Furlani, Giancarlo Balercia, Francesco Giorgino, Francesco Pallotti
Rok vydání: 2015
Předmět:
haplotype
Endocrinology
Diabetes and Metabolism
sexual function
protein binding
Review
Review Article
cancer risk
Bioinformatics
lcsh:Diseases of the endocrine glands. Clinical endocrinology
male infertility
Bone remodeling
Endocrinology
Prostate
androgen receptor
binding affinity
Medicine
oligospermia
media_common
CAG repeat
azoospermia
bone density
risk assessment
testosterone blood level
medicine.anatomical_structure
priority journal
risk factor
depression
disease severity
Repeat polymorphism
hormone action
prostate disease
Male sexual function
cardiovascular risk
erectile dysfunction
media_common.quotation_subject
Fertility
testis cancer
gene frequency
degenerative disease
human
protein interaction
AR gene
gene
testosterone
AR gene
body composition
bone metabolism
DNA polymorphism
gene function
hormone substitution
Testicular cancer
lcsh:RC648-665
Endocrine and Autonomic Systems
business.industry
Testosterone (patch)
medicine.disease
Androgen receptor
testosterone
business
Zdroj: International Journal of Endocrinology
International Journal of Endocrinology, Vol 2015 (2015)
ISSN: 1687-8345
1687-8337
DOI: 10.1155/2015/298107
Popis: In the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular risk, body composition, bone metabolism, the risk of prostate and testicular cancer, the psychiatric status, and the onset of neurodegenerative disorders. In this review, we extensively discuss the literature data and identify a role for AR CAG repeat polymorphism in conditioning the systemic testosterone effects. In particular, our main purpose was to provide an updated text able to shed light on the many and often contradictory findings reporting an influence of CAG repeat polymorphism on the targets of testosterone action.
Databáze: OpenAIRE
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